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ICD-10-CM is the official system of assigning codes to diagnoses and procedures associated with hospital utilization in the United States.

CDC released the FY2025 ICD-10-CM with 252 new codes,36 code deletions,13 code revisions making the cut, going into effect on October 1, 2024.

Key Features:
Index of Drugs and Chemicals
Index of Diseases and Injuries
Index of External Causes of Injuries
Index of Neoplasm
The National Center for Health Statistics (NCHS) and the Centers for Medicare and Medicaid Services are the U.S. governmental agencies responsible for overseeing all changes and modifications to the ICD-10-CM.

Highlights from the new 2025 ICD-10-CM codes
ICD-10 codes for cancer in remission
The neoplasm chapter contains codes for most benign and all malignant neoplasms. Chapter 2-Neoplasms leads the way this year in the quantity of new codes, receiving .63 new codes expanding cancer to include "in remission."
C81.1ANodular sclerosis Hodgkin lymphoma, in remission
C81.2AMixed cellularity Hodgkin lymphoma, in remission
C81.3ALymphocyte depleted Hodgkin lymphoma, in remission
C82.5ADiffuse follicle center lymphoma, in remission
C82.6ACutaneous follicle center lymphoma, in remission

Updates to ICD-10 codes for Hypolycemia & Obesity
Chapter 4 –Endocrine, nutritional & metabolic diseases adds level & class to Hypolycemia and Obesity.
E16.A2Hypoglycemia level 2
E16.A3Hypoglycemia level 3
E66.81Obesity class
E66.811Obesity,class 1
E74.82Disorders of citrate metabolism
E74.820SLC13A5 Citrate Transporter Disorder
E74.829Other disorders of citrate metabolism

ICD-10 codes for mental health disorders
In the 2025 update of ICD-10-CM,Chapter 5–Mental & Behavioral Disorders adds type & severity to eating disorders & 2 new codes for mental & behavioral conditions in adults.
F50.010 Anorexia nervosa, restricting type,mild
F50.023Anorexia nervosa, binge eating/purging type, xtreme
F50.21 Bulimia nervosa,mild
F50.814Binge eating disorder,in remission
F50.83Pica in adults
F50.84 Rumination disorder in adults

Updated ICD-10 codes for diseases of the digestive system
Chapter 11–Diseases of the Digestive System adds 5th & 6th character codes for conditions for 2025, providing additional details on the complexity of the condition.
K60.311Anal fistula, simple, initial
K60.32Anal fistula, complex
K60.413Rectal fistula, simple, recurrent
K60.422Rectal fistula, complex, persistent
K60.50 Anorectal fistula, unspecified

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Publisher:Centers for Disease Control & Prevention