The Scofield Reference Bible Commentary is a widely circulated study Bible edited and annotated by the American Bible student Cyrus I. Scofield, which popularized dispensationalism at the beginning of the 20th century. Published by Oxford University Press and containing the entire text of the traditional, Protestant King James Version, it first appeared in 1909 and was revised by the author in 1917

The Scofield Reference Bible had several innovative features. Most important, it printed what amounted to a commentary on the biblical text alongside the Bible instead of in a separate volume, the first to do so since the Geneva Bible (1560). It also contained a cross-referencing system that tied together related verses of Scripture and allowed a reader to follow biblical themes from one chapter and book to another (so called "chain references"). Finally, the 1917 edition also attempted to date events of the Bible. It was in the pages of the Scofield Reference Bible that many Christians first encountered Archbishop James Ussher's calculation of the date of Creation as 4004 BC; and through discussion of Scofield's notes, which advocated the "gap theory," fundamentalists began a serious internal debate about the nature and chronology of creation.

The Scofield Bible was published only a few years before World War I, a war that destroyed the cultural optimism that had viewed the world as entering a new era of peace and prosperity; then the post-World War II era witnessed the creation in Israel of a homeland for the Jews. Thus, Scofield's premillennialism seemed prophetic. "At the popular level, especially, many people came to regard the dispensationalist scheme as completely vindicated." Sales of the Reference Bible exceeded two million copies by the end of World War II. The Scofield Reference Bible promoted dispensationalism, the belief that between creation and the final judgment there would be seven distinct eras of God's dealing with man and that these eras are a framework for synthesizing the message of the Bible. It was largely through the influence of Scofield's notes that dispensationalism grew in influence among fundamentalist Christians in the United States. Scofield's notes on the Book of Revelation are a major source for the various timetables, judgments, and plagues elaborated on by popular religious writers such as Hal Lindsey, Edgar C. Whisenant, and