Sepsis Clinical Guide

Sepsis Clinical Guide now includes access the new ESCAVO Clinical Community, a forum where clinicians can exchange ideas, ask questions and collaborate on sepsis and other clinical topics.

Sepsis is a serious systemic infection that can quickly lead to circulatory shock, organ failure and death if inappropriately treated. In 2017, over 2 million people were admitted to US hospitals for sepsis (#1 cause of index admissions) at a total aggregate cost to the US healthcare system of $38.2 billion dollars (#1 most expensive condition), according to an AHRQ report. Over 270,000 people die of sepsis in the US every year, more than from prostate cancer, breast cancer and AIDS combined. Despite its large toll on public health, public awareness of this condition is poor and the quality of treatment is highly variable often due to delayed recognition and treatment.

In sepsis, time is of the essence. Successful treatment hinges on prompt recognition of symptoms, correct antibiotic administration, and hemodynamic stabilization. Lack of appropriate sepsis management knowledge at the bedside leads to delayed symptom recognition, serious complications, medical errors, increased treatment costs, and avoidable morbidity and mortality. For this reason, we created this app to provide busy health professionals with essential management information based on the latest practice guidelines in a format that is easily accessible at the point of care.

The Sepsis app was developed on the ESCAVO mobile publishing platform created specifically for mobile publishing of scientific content. The platform features an intuitive user interface, search, annotation and bookmarking functions, and calculator support. All content is extensively referenced and footnoted where appropriate.

Clinical topics covered in the Sepsis app include:
- Updated with the latest definitions, diagnostic criteria, and management guidelines including the 2016 Sepsis-3 definitions and the latest Surviving Sepsis Campaign (SSC) guidelines
- Epidemiology, risk factors and pathophysiology of sepsis and septic shock
- Common differentials and etiology, guidelines on performing appropriate H&P and workups
- Management of common causes including hospital-acquired pneumonia (HAP), ventilator-acquired pneumonia (VAP) and intra-abdominal infections
- Sepsis management bundles, early goal-directed therapy, hemodynamic man